Last update :
16/06/2024
References   References 1674  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Gilbert DL, Martinez JF.
Title : Concentration dependency of vancomycin hydrochloride compatibility with beta-lactam antibiotics during simulated Y-site administration.
Reference : Hosp Pharm ; 33: 1515-1522. 1998

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAmpicillin sodium Antibiotic
Incompatible 250 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 250 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1 >> 50 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 1/0.5 >> 50/25 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 250-125 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1/0.5 >> 250/125 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionCefazolin sodium Antibiotic
Incompatible 50 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 10 >> 200 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 ; 10 & 200 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionCefonicid sodium Antibiotic
Compatible 1 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 225 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Incompatible 10 >> 225 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
InjectionCefotaxime sodium Antibiotic
Incompatible 50 & 200 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 & 10 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 200 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionCefoxitin sodium Antibiotic
Incompatible 10 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 180 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 50 & 180 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
InjectionCeftazidime Antibiotic
Compatible 1 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 10 >> 200 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 200 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionCeftizoxime sodium Antibiotic
Compatible 1 >> 280 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Incompatible 280 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 50 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
InjectionCeftriaxone disodium Antibiotic
Incompatible 1 >> 250 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 250 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionCefuroxime sodium Antibiotic
Incompatible 10 >> 150 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 150 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionNafcillin sodium Antibiotic
Compatible 1 mg/ml + InjectionVancomycin hydrochloride 2 & 20 mg/ml + Glucose 5%
Incompatible 10 >> 250 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 10 >> 250 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionPiperacillin sodium Antibiotic
Incompatible 10 >> 250 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 200 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionPiperacillin sodium / tazobactam Antibiotic
Incompatible 10/1.25 >> 200/25 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1/0.125 >> 200/25 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1/0.125 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
InjectionTicarcillin / clavulanic acid Antibiotic
Incompatible 1/0.034 >> 200/6.7 mg/ml + InjectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1/0.034 >> 200/6.7 mg/ml + InjectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
InjectionVancomycin hydrochloride Antibiotic
Incompatible 20 mg/ml + InjectionAmpicillin sodium 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionAmpicillin sodium 1 >> 50 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionAmpicillin sodium 1 >> 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionAmpicillin sodium - sulbactam sodium 1/0.5 >> 50/25 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionAmpicillin sodium - sulbactam sodium 250-125 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionAmpicillin sodium - sulbactam sodium 1/0.5 >> 250/125 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCefazolin sodium 10 >> 200 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCefazolin sodium 1 ; 10 & 200 mg/ml + Glucose 5%
Incompatible 2 mg/ml + InjectionCefazolin sodium 50 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionCefazolin sodium 1 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionCefonicid sodium 1 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCefonicid sodium 1 >> 225 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCefonicid sodium 10 >> 225 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionCefotaxime sodium 1 & 10 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCefotaxime sodium 1 >> 200 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCefotaxime sodium 50 & 200 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCefoxitin sodium 1 >> 180 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCefoxitin sodium 50 & 180 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionCefoxitin sodium 1 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCefoxitin sodium 10 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCeftazidime 1 >> 200 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionCeftazidime 1 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCeftazidime 10 >> 200 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionCeftizoxime sodium 1 >> 50 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCeftizoxime sodium 1 >> 280 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCeftizoxime sodium 280 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCeftriaxone disodium 1 >> 250 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCeftriaxone disodium 1 >> 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionCefuroxime sodium 1 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionCefuroxime sodium 1 >> 150 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionCefuroxime sodium 10 >> 150 mg/ml + Glucose 5%
Compatible 2 & 20 mg/ml + InjectionNafcillin sodium 1 mg/ml + Glucose 5%
Incompatible 2 mg/ml + InjectionNafcillin sodium 10 >> 250 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionNafcillin sodium 10 >> 250 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionPiperacillin sodium 10 >> 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionPiperacillin sodium 1 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionPiperacillin sodium 1 >> 200 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionPiperacillin sodium / tazobactam 10/1.25 >> 200/25 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 1/0.125 >> 200/25 mg/ml + Glucose 5%
Compatible 20 mg/ml + InjectionPiperacillin sodium / tazobactam 1/0.125 mg/ml + Glucose 5%
Incompatible 20 mg/ml + InjectionTicarcillin / clavulanic acid 1/0.034 >> 200/6.7 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionTicarcillin / clavulanic acid 1/0.034 >> 200/6.7 mg/ml + Glucose 5%

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