Last update :
17/04/2024
References   References 1452  
Type : Journal

Research teams : Friedberg - Fresenius Kabi, Innovation Centre i.v. Therapies
Authors : Muller HJ, Howe K, Frank C, Haker I.
Title : Stability of cefazolin, cefotiam, cefuroxime, cefotaxime, ceftriaxone and ceftazidime in normal saline solutions, stored in a new IV container made of Biofine*.
Reference : Eur Hosp Pharm ; 6: 17-23. 2000

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionCefazolin sodium Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 10 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,9% 10 mg/ml 25°C Not specified
7 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 10 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 10 mg/ml 25°C Not specified
7 Day
InjectionCefotaxime sodium Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
24 Hour
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
24 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 25°C Not specified
24 Hour
InjectionCeftazidime Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
10 Day
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 25°C Not specified
2 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
10 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 25°C Not specified
2 Day
InjectionCeftriaxone disodium Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 25°C Not specified
5 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 25°C Not specified
5 Day
InjectionCefuroxime sodium Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 7,5 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass Sodium chloride 0,9% 7,5 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 7,5 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 7,5 mg/ml 25°C Not specified
24 Hour

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