Last update :
21/09/2021
References   References 2042  
Type : Journal
Web link : http://aac.asm.org/cgi/content/abstract/46/8/2327

Research teams : Louvain - Drug Research Institute, University of Louvain
Authors : Viaene E, Chanteux H, Servais H, Mingeot-Leclerq MP, Tulkens PM.
Title : Comparative stability studies of antipseudomonal ß-lactams for potential administration through portable elastomeric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units).
Reference : Antimicrob Agents Chemother ; 46: 2327-2332. 2002

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No visual inspection
Unencrypted results (eg graphic)

List of drugs
InjectionAztreonam Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 100 mg/ml 37°C Not specified
24 Hour
InjectionCefepime dihydrochloride Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 50 mg/ml 25°C Not specified
20 Hour
Stability in solutions Elastomer (unspecified) Water for Injection 50 mg/ml 37°C Not specified
13 Hour
InjectionCefpirome sulfate Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 32 mg/ml 25°C Not specified
23 Hour
Stability in solutions Elastomer (unspecified) Water for Injection 32 mg/ml 37°C Not specified
7 Hour
InjectionCeftazidime Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 120 mg/ml 25°C Not specified
24 Hour
Stability in solutions Elastomer (unspecified) Water for Injection 120 mg/ml 37°C Not specified
8 Hour
InjectionImipenem - cilastatin sodium Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 8 mg/ml 25°C Not specified
3 Hour
Stability in solutions Elastomer (unspecified) Water for Injection 8 mg/ml 37°C Not specified
2 Hour
InjectionMeropenem Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 64 mg/ml 25°C Not specified
5 Hour
Stability in solutions Elastomer (unspecified) Water for Injection 64 mg/ml 37°C Not specified
1 Hour
InjectionPiperacillin sodium Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 128 mg/ml 25°C Not specified
30 Hour
Stability in solutions Elastomer (unspecified) Water for Injection 128 mg/ml 37°C Not specified
21 Hour
InjectionPiperacillin sodium / tazobactam Antibiotic
Stability in solutions Elastomer (unspecified) Water for Injection 128 / 16 mg/ml 25°C Not specified
72 Hour
Stability in solutions Elastomer (unspecified) Water for Injection 128 / 16 mg/ml 37°C Not specified
24 Hour

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