Last update :
20/01/2021
Analgesic   Diamorphine hydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Incompatibilities Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Diamorphine hydrochloride for injection Great Britain
Diaphin Switzerland
References   Injection   References : Diamorphine hydrochloride  
Type Publication
339 Journal Kleinberg ML, Duafala ME, Nacov C, Flora KP, Hines J, Davis K, McDaniel A, Scott D.
Stability of heroin hydrochloride in infusion devices and containers for intravenous administration.
Am J Hosp Pharm 1990 ; 47: 377-381.
484 Journal Northcott M, Allsopp MA, Powell H, Sewell GJ.
The stability of carboplatin, diamorphine, 5-fluorouracil and mitozantrone infusions in an ambulatory pump under storage and prolonged “in use” conditions.
J Clin Pharm Ther 1991 ; 16: 123-129.
506 Journal Omar OA, Hoskin PJ, Johnston A, Hanks W, Turner P.
Diamorphine stability in aqueous solution for subcutaneous infusion.
J Pharm Pharmacol 1989 ; 41: 275-277.
512 Journal Barnes AR, Nash S.
Stability of bupivacaine hydrochloride with diamorphine hydrochloride in an epidural infusion.
Pharm World Sci 1995 ; 17: 87-92.
779 Journal Collins AJ, Abethell JA, Holmes SG, Rain R.
Stability of diamorphine hydrochloride with haloperidol in prefilled syringes for continuous subcutaneous administration.
J Pharm Pharmacol 1986 ; 38: 51P.
788 Journal Regnard CFB, Mannix K.
Subcutaneous drug compatibility in palliative care.
Lancet 1989 ; 2 (8670): 1044-1045.
1230 Journal Regnard C, Pashley S, Westrope F.
Anti-emetic / diamorphine mixture compatibility in infusion pumps.
Br J Pharm Pract 1986 ; 8: 218-220.
1288 Journal Allwood MC, Brown PW, Lee M.
Stability of injections containing diamorphine and midazolam in plastic syringes.
Int J Pharm Pract 1994 ; 3: 57-59.
1292 Journal Grassby PF, Roberts DE.
Stability of epidural opiate solutions in 0.9 per cent sodium chloride infusion bags.
Int J Pharm Pract 1995 ; 3: 174-177.
1385 Journal Kirk B, Hain WR.
Diamorphine injection BP incompatibility.
Pharm J 1985 ; 235: 171.
1388 Journal Page J, Hudson S.
Diamorphine hydrochloride compatibility with saline.
Pharm J 1982 ; 228: 238-239.
1886 Journal Allwood MC.
The stability of diamorphine alone and in combinaison with antiemetics in plastic syringes.
Palliative Med 1991 ; 5: 330-333.
2051 Journal Sanchez del Aguila MJ, Jones MF, Vohra A.
Premixed solutions of diamorphine in ropivacaine for epidural anaesthesia: a study on long-term stability.
Br J Anaesth 2003 ; 90: 179-182.
2307 Journal Kreeger L, Cowin P, Noble-Gresty J, Naysmith A.
Epidural diamorphine and bupivacaine stability study.
Palliative Med 1995 ; 9, 4: 315-318.
2308 Journal Hudson S.J, Jones M.F, Nolan S, Ellis H, Duncombe R, Alexander-Williams J.M.
Stability of premixed syringes of diamorphine and hyperbaric bupivacaine.
Int J Obstet Anesth 2005 ; 14, 4: 284-287.
3504 Manufacturer Parecoxib (Dynastat®) - Summary of Product Characteristics
Pfizer 2012

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