Last update :
20/01/2021
References   References 484  
Type : Journal PC : 0.0006830601092896 

Research teams : Exeter - University of Exeter
Authors : Northcott M, Allsopp MA, Powell H, Sewell GJ.
Title : The stability of carboplatin, diamorphine, 5-fluorouracil and mitozantrone infusions in an ambulatory pump under storage and prolonged “in use” conditions.
Reference : J Clin Pharm Ther ; 16: 123-129. 1991

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Water loss by evaporation 
Comments : 
No comments for the degradation products

List of drugs
InjectionCarboplatin Anticancer drug
Stability in solutions Polyvinyl chloride Water for Injection 1 mg/ml 37°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride Water for Injection 1 mg/ml 4°C Protect from light
14 Day
InjectionDiamorphine hydrochloride Analgesic
Stability in solutions Polyvinyl chloride Water for Injection 5 mg/ml 37°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Water for Injection 5 mg/ml 4°C Protect from light
14 Day
InjectionFluorouracil Anticancer drug
Stability in solutions Polyvinyl chloride None 25 mg/ml 37°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride None 25 mg/ml 4°C Protect from light
14 Day
InjectionMitoxantrone dihydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride Water for Injection 0,2 mg/ml 37°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride Water for Injection 0,2 mg/ml 4°C Protect from light
14 Day

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