Last update :
17/04/2024
References   References 644  
Type : Journal

Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Marble DA, Bosso JA, Townsend RJ.
Title : Compatibility of clindamycin phosphate with aztreonam in polypropylene syringes and with cefoperazone sodium, cefonicid sodium, and cefuroxime sodium in partial-fill glass bottles.
Reference : Drug Intell Clin Pharm ; 22: 54-57. 1988

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
InjectionAztreonam Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 20 mg/ml 25°C Light
48 Hour
Compatible 200 mg/ml + InjectionClindamycin phosphate 60 mg/ml + Sodium chloride 0,9%
InjectionCefonicid sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Compatible 10 mg/ml + InjectionClindamycin phosphate 12 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCefoperazone sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + InjectionClindamycin phosphate 12 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCefuroxime sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 15 mg/ml 25°C Light
48 Hour
Compatible 15 mg/ml + InjectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
InjectionClindamycin phosphate Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 60 mg/ml 25°C Light
48 Hour
Compatible 60 mg/ml + InjectionAztreonam 200 mg/ml + Sodium chloride 0,9%
Compatible 12 mg/ml + InjectionCefonicid sodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 12 mg/ml + InjectionCefoperazone sodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + InjectionCefuroxime sodium 15 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 25°C Light
Injection Clindamycin phosphate 12 mg/ml
Injection Cefoperazone sodium 20 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
Injection Clindamycin phosphate 12 mg/ml
Injection Cefonicid sodium 10 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Cefuroxime sodium 15 mg/ml
48 Hour
Glass Sodium chloride 0,9% 25°C Light
Injection Clindamycin phosphate 60 mg/ml
Injection Aztreonam 200 mg/ml
48 Hour

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