Last update :
23/11/2022
References   References 4691  
Type : Journal

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Catry E, Colsoul ML, Closset Me, Hubert J, Soumoy L, Bihin B, Thiry E, Jamart J, Hecq JD, Galanti L.
Title : Physical and Chemical Stability of Pharmaceutical Preparation of Bumetanide and Scopolamine.
Reference : Int J Pharm Compound ;26,3:248-254 2022

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionBumetanide Diuretic
InjectionScopolamine hydrobromide Antimuscarinic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Not specified
Injection Bumetanide 0,0417 mg/ml
Injection Scopolamine hydrobromide 0,0052 mg/ml
18 Day
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Not specified
Injection Bumetanide 0,125 mg/ml
Injection Scopolamine hydrobromide 0,0312 mg/ml
18 Day

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