Last update :
28/04/2024
References   References 360  
Type : Journal

Research teams : Nagoya - Meijo University, Faculty of Pharmacy
Authors : Inagaki K, Gill MA, Okamoto MP, Takagi J.
Title : Stability of ranitidine hydrochloride with aztreonam, ceftazidime, or piperacillin sodium during simulated Y-site administration.
Reference : Am J Hosp Pharm ; 49: 2769-2772. 1992

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No visual inspection

List of drugs
InjectionAztreonam Antibiotic
InjectionCeftazidime Antibiotic
InjectionPiperacillin sodium Antibiotic
InjectionRanitidine hydrochloride Antihistamine (H2)
Stability of mixtures
Glass Not specified 23°C Light
Injection Aztreonam 8,6 mg/ml
Injection Ranitidine hydrochloride 0,5 mg/ml
4 Hour
Glass Not specified 23°C Light
Injection Ceftazidime 10 mg/ml
Injection Ranitidine hydrochloride 0,5 mg/ml
4 Hour
Glass Sodium chloride 0,9% 22°C-23°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Aztreonam 8,6 mg/ml
4 Hour
Glass Sodium chloride 0,9% 22°C-23°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Ceftazidime 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 22°C-23°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Piperacillin sodium 15 mg/ml
4 Hour

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