Last update :
15/04/2024
References   References 280  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/52/21/2427

Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Allen LV, Stiles ML, Prince SJ, Sylvestri MF.
Title : Stability of cefpirome sulfate in the presence of commonly used intensive care drugs during simulated Y-site injection.
Reference : Am J Health-Syst Pharm ; 52: 2427-2433. 1995

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 5 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
InjectionAmphotericin B Antifungal
Incompatible 0.1 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Incompatible 0.1 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Incompatible 0.1 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCefazolin sodium Antibiotic
Compatible 10 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 10 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 10 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
InjectionCefpirome sulfate Antibiotic
Compatible 50 mg/ml + InjectionAmikacin sulfate 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionAmikacin sulfate 5 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,45%
Incompatible 50 mg/ml + InjectionAmphotericin B 0.1 mg/ml + Ringer’s lactate solution
Incompatible 50 mg/ml + InjectionAmphotericin B 0.1 mg/ml + Sodium chloride 0,45%
Incompatible 50 mg/ml + InjectionAmphotericin B 0.1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionCefazolin sodium 10 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionCefazolin sodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionCefazolin sodium 10 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionClindamycin phosphate 12 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionClindamycin phosphate 12 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionClindamycin phosphate 12 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionDopamine hydrochloride 0.8 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionDopamine hydrochloride 0.8 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionDopamine hydrochloride 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionEpinephrine hydrochloride 100 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionEpinephrine hydrochloride 100 µg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionEpinephrine hydrochloride 100 µg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionFluconazole 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionFluconazole 2 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionFluconazole 2 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionGentamicin sulfate 1 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionGentamicin sulfate 1 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionGentamicin sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + InjectionVancomycin hydrochloride 5 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + InjectionVancomycin hydrochloride 5 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + InjectionVancomycin hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionClindamycin phosphate Antibiotic
Compatible 12 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 12 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 12 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 4 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
InjectionDopamine hydrochloride Cardiotonic
Compatible 0.8 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 0.8 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.8 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 100 µg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 100 µg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 100 µg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
InjectionGentamicin sulfate Antibiotic
Compatible 1 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 1 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 1 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
InjectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 5 mg/ml + InjectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 5 mg/ml + InjectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Cefazolin sodium 10 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Dexamethasone sodium phosphate 4 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Dopamine hydrochloride 0,8 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Epinephrine hydrochloride 0,1 µg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Amikacin sulfate 5 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Clindamycin phosphate 12 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Fluconazole 2 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Gentamicin sulfate 1 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Vancomycin hydrochloride 5 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Cefazolin sodium 10 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Dexamethasone sodium phosphate 4 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Dopamine hydrochloride 0,8 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Epinephrine hydrochloride 0,1 µg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Amikacin sulfate 5 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Clindamycin phosphate 12 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Fluconazole 2 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Gentamicin sulfate 1 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Vancomycin hydrochloride 5 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Cefazolin sodium 10 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Dexamethasone sodium phosphate 4 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Dopamine hydrochloride 0,8 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
Injection Cefpirome sulfate 50 mg/ml
Injection Epinephrine hydrochloride 0,1 µg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Amikacin sulfate 5 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Clindamycin phosphate 12 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Fluconazole 2 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Gentamicin sulfate 1 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
Injection Cefpirome sulfate 50 mg/ml
Injection Vancomycin hydrochloride 5 mg/ml
8 Hour

  Mentions Légales