Last update :
03/05/2024
References   References 1497  
Type : Journal

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker SE, Iazetta J, DeAngelis C, Lau DWC.
Title : Stability and compatibility of combinations of hydromorphone and dimenhydrinate lorazepam or prochlorperazine.
Reference : Can J Hosp Pharm ; 46: 61-65. 1993

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionDimenhydrinate Antihistamine (H1)
Compatible 50 mg/ml + InjectionHydromorphone hydrochloride 2 >> 40 mg/ml + None
InjectionHydromorphone hydrochloride Analgesic
Compatible 2 >> 40 mg/ml + InjectionDimenhydrinate 50 mg/ml + None
Compatible 2 >> 40 mg/ml + InjectionLorazepam 4 mg/ml + None
Compatible 2 >> 40 mg/ml + InjectionProchlorperazine edysilate 5 mg/ml + None
InjectionLorazepam Anxiolytic
Compatible 4 mg/ml + InjectionHydromorphone hydrochloride 2 >> 40 mg/ml + None
InjectionProchlorperazine edysilate Neuroleptic
Compatible 5 mg/ml + InjectionHydromorphone hydrochloride 2 >> 40 mg/ml + None
Stability of mixtures
Glass None 23°C Not specified
Injection Hydromorphone hydrochloride 2 & 10 & 40 mg/ml
Injection Dimenhydrinate 50 mg/ml
24 Hour
Glass None 37°C Not specified
Injection Hydromorphone hydrochloride 2 & 10 & 40 mg/ml
Injection Dimenhydrinate 50 mg/ml
24 Hour
Glass None 4°C Protect from light
Injection Hydromorphone hydrochloride 2 & 10 & 40 mg/ml
Injection Dimenhydrinate 50 mg/ml
24 Hour

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