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References   References 1193  
Type : Journal
Research teams : Brooklyn - Long Island University, Arnold and Marie Schwarz College of Pharmacy
Authors : Perentesis GP, Plitz GW, Kirschenbaum HL, Navalakha P, Aronoff W, Cutie AJ.
Title : Stability and visual compatibility of bretylium tosylate with selected large-volume parenterals and additives.
Reference : Am J Hosp Pharm ; 40: 1010-1012. 1983
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
ultraviolet spectrometry
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Method not shown but the article refers to a validated method
List of drugs
injectionAminophylline Various
Compatible 1 mg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionBretylium tosilate Anti-arrhythmic
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 25°C Light
30 Day
Stability in solutions Glass Glucose 5% 1 mg/ml 25°C Light
48 Hour
Stability in solutions Glass Ringer’s lactate solution 1 mg/ml 25°C Light
30 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 25°C Light
30 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 1 mg/ml 25°C Light
30 Day
Compatible 1 mg/ml + injectionAminophylline 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionCalcium gluconate 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionDigoxin 2 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionPhenytoin sodium 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionProcainamide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionQuinidine gluconate 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible + Sodium chloride 0,9%
Compatible + Glucose 5%
Compatible + Ringer’s lactate solution
injectionCalcium gluconate Electrolyte
Compatible 2 mg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionDigoxin Cardiotonic
Compatible 2 µg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 2 mg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionPhenytoin sodium Antiepileptic
Incompatible 2 mg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionProcainamide hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionQuinidine gluconate Anti-arrhythmic
Compatible 0.8 mg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
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