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References   References 1193  
Type : Journal
Research teams : Brooklyn - Long Island University, Arnold and Marie Schwarz College of Pharmacy
Authors : Perentesis GP, Plitz GW, Kirschenbaum HL, Navalakha P, Aronoff W, Cutie AJ.
Title : Stability and visual compatibility of bretylium tosylate with selected large-volume parenterals and additives.
Reference : Am J Hosp Pharm ; 40: 1010-1012. 1983
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Ultraviolet spectrometry
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Method not shown but the article refers to a validated method
List of drugs
InjectionAminophylline Various
Compatible 1 mg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionBretylium tosilate Anti-arrhythmic
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 25°C Light
30 Day
Stability in solutions Glass Glucose 5% 1 mg/ml 25°C Light
48 Hour
Stability in solutions Glass Ringer’s lactate solution 1 mg/ml 25°C Light
30 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 25°C Light
30 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 1 mg/ml 25°C Light
30 Day
Compatible 1 mg/ml + InjectionAminophylline 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionCalcium gluconate 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionDigoxin 2 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionPhenytoin sodium 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionProcainamide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionQuinidine gluconate 0.8 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCalcium gluconate Electrolyte
Compatible 2 mg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDigoxin Cardiotonic
Compatible 2 µg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionLidocaine hydrochloride Local anesthetic
Compatible 2 mg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPhenytoin sodium Antiepileptic
Incompatible 2 mg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionProcainamide hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionQuinidine gluconate Anti-arrhythmic
Compatible 0.8 mg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
  Mentions Légales