Bibliographie - 513 - Stabilis 4.0

Last update :
21/01/2026

References 513

Type :

Journal

Web link :

https://doi.org/10.1177/106002809603000709

Research teams :

Houston - M.D.Anderson Cancer Center

Authors :

Xu QA, Trissel LA, Martinez JF.

Title :

Stability and compatibility of fluorouracil with morphine sulfate and hydromorphone hydrochloride.

Reference :

Ann Pharmacotherapy ; 30: 756-761. 1996

Level of Evidence :

Physical stability :

Chemical stability :

Stability defined as 95% of the initial concentration

High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)

Other methods :

Comments :

Degradation products not observed in real conditions

List of drugs

Fluorouracil

1 & 16 mg/ml	+ Hydromorphone hydrochloride	0.5 mg/ml	+
1 & 16 mg/ml	+ Hydromorphone hydrochloride	0.5 mg/ml	+
1 & 16 mg/ml	+ Morphine sulfate	1 mg/ml	+
1 & 16 mg/ml	+ Morphine sulfate	1 mg/ml	+

Hydromorphone hydrochloride

	0.5 mg/ml	+ Fluorouracil	1 & 16 mg/ml	+
	0.5 mg/ml	+ Fluorouracil	1 & 16 mg/ml	+

Morphine sulfate

	1 mg/ml	+ Fluorouracil	1 & 16 mg/ml	+
	1 mg/ml	+ Fluorouracil	1 & 16 mg/ml	+

-20°C

Fluorouracil	1 & 16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

23°C

Fluorouracil	16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

23°C

Fluorouracil	1 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

32°C

Fluorouracil	16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

32°C

Fluorouracil	1 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

4°C

Fluorouracil	1 & 16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

-20°C

Fluorouracil	1 & 16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

23°C

Fluorouracil	16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

23°C

Fluorouracil	1 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

32°C

Fluorouracil	16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

32°C

Fluorouracil	1 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

4°C

Fluorouracil	1 & 16 mg/ml
Hydromorphone hydrochloride	0,5 mg/ml

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