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Anti-inflammatory   Methylprednisolone sodium succinate  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Methylprednisolone France
Metypred Poland
Prednol Turkey
Solomet Finland
Solu-Medrol Austria, Brazil, Canada, Croatia, Denmark, Finland, France, Italy, Netherlands, Norway, Poland, Portugal, Republic of South Africa, Slovenia, Sweden, Switzerland, United States of America
Solu-Medrone Great Britain, Ireland
Urbason Austria, Italy, Spain
Stability of mixtures   Injection   Stability of mixtures : Methylprednisolone sodium succinate     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass Glucose 5% 0,5 & 2 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Theophylline 0,4 mg/ml
37°C
12 Hour
Light 391
Glass Glucose 5% 0,5 & 2 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Theophylline 4 mg/ml
37°C
24 Hour
Light 391
Polyvinyl chloride NaCl 0,9% or Glucose 5% 2,26 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Granisetron hydrochloride 0,056 mg/ml
22°C
3 Day
Protect from light 29
Polyvinyl chloride Sodium chloride 0,9% 0,04 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Ranitidine hydrochloride 0,05 mg/ml
?
24 Hour
Not specified 210
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Ranitidine hydrochloride 0,05 & 2 mg/ml
?
24 Hour
Not specified 210
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,04 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Ranitidine hydrochloride 2 mg/ml
?
48 Hour
Not specified 210
Level of evidence B
Polyvinyl chloride Glucose 5% 0,4 & 1,25 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Cimetidine hydrochloride 3 mg/ml
24°C
24 Hour
Not specified 211
Level of evidence B+
Polyvinyl chloride Glucose 5% 0,04 & 2 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Ranitidine hydrochloride 0,05 & 2 mg/ml
?
48 Hour
Not specified 210
Level of evidence B
Polyolefine NaCl 0,9% or Glucose 5% 2,4 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Ondansetron hydrochloride 0,16 mg/ml
20°C-25°C
24 Hour
Light 2012
Polyolefine NaCl 0,9% or Glucose 5% 2,4 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Ondansetron hydrochloride 0,16 mg/ml
4°C
48 Hour
Not specified 2012
Polypropylen Syringe NaCl 0,9% or Glucose 5% 6 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Granisetron hydrochloride 0,15 mg/ml
22°C
3 Day
Protect from light 29
Polypropylen Syringe Sodium chloride 0,9% 0,8 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Methotrexate sodium 5,3 mg/ml
24-26°C
6 Hour
Protect from light 4641
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,5 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Methotrexate sodium 3 mg/ml
24-26°C
6 Hour
Protect from light 4641
Level of evidence A+
Polypropylen Syringe None 0,51 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Methotrexate sodium 1,54 mg/ml
Injection   Cytarabine 3,85 mg/ml
5°C
12 Hour
Protect from light 3275
Level of evidence A
Not specified NaCl 0,9% or Glucose 5% 1,2 mg/ml
Injection   Methylprednisolone sodium succinate   
Injection   Topotecan 0,028 mg/ml
20°C-23°C
4 Hour
Light 1026
Level of evidence C
  Mentions Légales