Last update :
12/06/2024
Cytoprotective   Levofolinate calcium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Calc Levof Italy
Calcium levofolinat Austria
Elvorine Belgium, France, Luxembourg, Morocco
Folaxin Spain
Folinate EG Belgium
Isovorin Austria, Denmark, Finland, Great Britain, Greece, Iceland, Spain, Sweden
Levofolatino de calcio Portugal
Levofolene Italy
Compatibility   Injection   Compatibility : Levofolinate calcium              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Levofolinate calcium 2 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Chemical instability Incompatible
Injection Levofolinate calcium
Injection Bleomycin sulfate
4154
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Cefamandole nafate
3546
Immediate precipitation Incompatible
Injection Levofolinate calcium
Injection Ceftriaxone disodium
3523
Immediate precipitation Incompatible
Injection Levofolinate calcium
Injection Ceftriaxone disodium
Ringer’s lactate solution 3523
Precipitation after 24 hours Incompatible
Injection Levofolinate calcium 1.54 >> 13.33 mg/ml
Injection Fluorouracil 16.67 >> 46.15 mg/ml
Glucose 5% 155
Compatible
Injection Levofolinate calcium 1,8 mg/ml
Injection Fluorouracil 10,8 mg/ml
NaCl 0,9% or Glucose 5% 3369
Chemical instability Incompatible
Injection Levofolinate calcium 4 mg/ml
Injection Fluorouracil 6.5 mg/ml
NaCl 0,9% or Glucose 5% 2181
Compatible
Injection Levofolinate calcium 15.4 mg/ml
Injection Fluorouracil 50 mg/ml
NaCl 0,9% or Glucose 5% 2181
Compatible
Injection Levofolinate calcium 15.4 mg/ml
Injection Fluorouracil 6.5 mg/ml
2130
Immediate precipitation Incompatible
Injection Levofolinate calcium 15.4 mg/ml
Injection Fluorouracil 50 mg/ml
2130
Precipitation after 24 hours Incompatible
Injection Levofolinate calcium 1.54 >> 13.33 mg/ml
Injection Fluorouracil 16.67 >> 46.15 mg/ml
None 155
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Fosaprepitant dimeglumine
2295
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Foscarnet sodium
3662
Compatible
Injection Levofolinate calcium 0,2 mg/ml
Injection Irinotecan 0,2 mg/ml
NaCl 0,9% or Glucose 5% 3369
Compatible
Injection Levofolinate calcium 1,5 mg/ml
Injection Irinotecan 1,5 mg/ml
NaCl 0,9% or Glucose 5% 3369
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Magnesium sulfate
3838
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Omadacycline
4720
Compatible
Injection Levofolinate calcium 1,8 mg/ml
Injection Oxaliplatin 1,53 mg/ml
Glucose 5% 3369
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Pamidronate disodium
3619
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Pemetrexed disodium
1914
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Potassium phosphate
3621
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Tedizolid phosphate
3753
Unspecified incompatibility Incompatible
Injection Levofolinate calcium
Injection Zoledronic acid
3933

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