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References   References 813  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/56/1/63
Research teams : Decatur - Emory University System of Health Care
Authors : Akkermann SR, Zhang H, Mullins RE, Yaughn K.
Title : Stability of milrinone lactate in the presence of 29 critical care drugs and 4 IV solutions.
Reference : Am J Health-Syst Pharm ; 56: 63-68. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionAtracurium besylate Curarimimetic
Compatible 2 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionBumetanide Diuretic
Compatible 0.5 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionCalcium gluconate Electrolyte
Compatible 200 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 2 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 16 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 12.8 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 128 µg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionFentanyl citrate Analgesic
Compatible 100 µg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 200 UI/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionInsulin Glucose-lowering
Compatible 2 UI/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.016 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionLorazepam Anxiolytic
Compatible 0.4 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 80 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 2 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionMilrinone lactate Cardiotonic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,4 mg/ml 22°C-23°C Light
7 Day
Stability in solutions Polyvinyl chloride Glucose 5% 0,4 mg/ml 22°C-23°C Light
7 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0,4 mg/ml 22°C-23°C Light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,45% 0,4 mg/ml 22°C-23°C Light
7 Day
Compatible 0.8 mg/ml + Parenteral nutrition (binary mixture)
Compatible 0.8 mg/ml + InjectionAtracurium besylate 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionBumetanide 0.5 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionCalcium gluconate 200 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionCimetidine hydrochloride 12 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionDiltiazem hydrochloride 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionDobutamine hydrochloride 16 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionDopamine hydrochloride 12.8 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionEpinephrine hydrochloride 128 µg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionFentanyl citrate 100 µg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionHeparin sodium 200 UI/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionInsulin 2 UI/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionIsoprenaline hydrochloride 0.016 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionLorazepam 0.4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionMagnesium sulfate 80 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionMidazolam hydrochloride 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionMorphine sulfate 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionNitroglycerin 1.6 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionNitroprusside sodium 1.6 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionNorepinephrine bitartrate 0.128 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionPancuronium bromide 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionPotassium chloride 2000 mEq/l + Glucose 5%
Compatible 0.8 mg/ml + InjectionPropofol 20 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionRanitidine hydrochloride 4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionRocuronium bromide 4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionSodium bicarbonate 168 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionTheophylline 3.2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionTorsemide 20 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + InjectionVecuronium bromide 2 mg/ml + Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 2 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionNitroglycerin Vasodilator
Compatible 1.6 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionNitroprusside sodium Vasodilator
Compatible 1.6 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.128 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionPancuronium bromide Curarimimetic
Compatible 2 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionPotassium chloride Electrolyte
Compatible 2000 mEq/l + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionPropofol General anesthetic
Compatible 20 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 4 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionRocuronium bromide Curarimimetic
Compatible 4 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionSodium bicarbonate Electrolyte
Compatible 168 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionTheophylline Various
Compatible 3.2 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionTorsemide Diuretic
Compatible 20 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
InjectionVecuronium bromide Curarimimetic
Compatible 2 mg/ml + InjectionMilrinone lactate 0.8 mg/ml + Glucose 5%
Stability of mixtures
Glass Sodium chloride 0,9% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Insulin 0,8 UI/ml
4 Hour
Glass Glucose 5% 22°C-23°C Protect from light
Injection Milrinone lactate 0,2 mg/ml
Injection Nitroprusside sodium 0,4 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Nitroglycerin 0,4 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Dopamine hydrochloride 3,1 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Dobutamine hydrochloride 4 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Epinephrine hydrochloride 0,03 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Norepinephrine bitartrate 0,03 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Ranitidine hydrochloride 0,85 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Cimetidine hydrochloride 2,9 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Pancuronium bromide 0,46 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Atracurium besylate 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Diltiazem hydrochloride 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Bumetanide 0,12 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Theophylline 0,89 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Propofol 5,3 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Heparin sodium 59 UI/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Morphine sulfate 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Lorazepam 0,1 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Midazolam hydrochloride 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Fentanyl citrate 25 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Isoprenaline hydrochloride 3,7 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Vecuronium bromide 0,52 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Rocuronium bromide 1 mg/ml
4 Hour
  Mentions Légales