Last update :
10/07/2024
References   References 639  
Type : Journal

Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Zbrozek AS, Marble DA, Bosso JA, Bair JN, Townsend RJ.
Title : Compatibility and stability of clindamycin phosphate - aminoglycoside combinations within polypropylene syringes.
Reference : Drug Intell Clin Pharm ; 21: 806-810. 1987

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Method not shown but the article refers to a validated method
Increased concentration unexplained
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
injectionAmikacin sulfate Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 190 mg/ml 22°C-23°C Light
48 Hour
Compatible 75 mg/ml + injectionClindamycin phosphate 90 mg/ml + Sodium chloride 0,9%
injectionClindamycin phosphate Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 150 mg/ml 22°C-23°C Light
48 Hour
Compatible 90 mg/ml + injectionAmikacin sulfate 75 mg/ml + Sodium chloride 0,9%
Compatible 90 mg/ml + injectionGentamicin sulfate 12 mg/ml + Sodium chloride 0,9%
Incompatible 90 mg/ml + injectionTobramycin sulfate 12 mg/ml + Sodium chloride 0,9%
injectionGentamicin sulfate Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 30 mg/ml 22°C-23°C Light
48 Hour
Compatible 12 mg/ml + injectionClindamycin phosphate 90 mg/ml + Sodium chloride 0,9%
injectionTobramycin sulfate Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 30 mg/ml 22°C-23°C Light
48 Hour
Incompatible 12 mg/ml + injectionClindamycin phosphate 90 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 22°C-23°C Light
injection Clindamycin phosphate 90 mg/ml
injection Gentamicin sulfate 30 mg/ml
48 Hour
Polypropylen Syringe Sodium chloride 0,9% 22°C-23°C Light
injection Clindamycin phosphate 90 mg/ml
injection Amikacin sulfate 190 mg/ml
48 Hour

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