Last update :
16/06/2024
References   References 539  
Type : Journal

Research teams : Boston - New England Deaconess Hospital
Authors : Baptista RJ, Mitrano FP.
Title : Stability and compatibility of cimetidine hydrochloride and aminophylline in dextrose 5% in water injection.
Reference : Drug Intell Clin Pharm ; 22: 592-593. 1988

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Method not shown but the article refers to a validated method

List of drugs
InjectionAminophylline Various
Stability in solutions Polyvinyl chloride Glucose 5% 0,5 mg/ml 25°C Protect from light
48 Hour
Compatible 0,5 mg/ml + InjectionCimetidine hydrochloride 1,2 mg/ml + Glucose 5%
InjectionCimetidine hydrochloride Antihistamine (H2)
Stability in solutions Polyvinyl chloride Glucose 5% 1,2 mg/ml 25°C Protect from light
48 Hour
Compatible 1,2 mg/ml + InjectionAminophylline 0,5 mg/ml + Glucose 5%
Stability of mixtures
Polyvinyl chloride Glucose 5% 25°C Protect from light
Injection Cimetidine hydrochloride 1,2 mg/ml
Injection Aminophylline 0,5 mg/ml
48 Hour

  Mentions Légales