Last update :
10/07/2024
References   References 4763  
Type : Journal
Web link : https://www.degruyter.com/document/doi/10.1515/pthp-2023-0003/html

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Almasi J, Erdnuss F, Thiesen J, Krämer I.
Title : Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL)
Reference : Pharmaceutical Technology in Hospital Pharmacy ;8,1 2023

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Degradation products detected but not quantified

List of drugs
injectionMitomycin Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Glass Water for Injection 1 mg/ml 20-25°C Protect from light
6 Hour
Stability in solutions Polypropylen Syringe Water for Injection 2 mg/ml 2-8°C Protect from light
8 Hour
Stability in solutions Polypropylen Syringe Water for Injection 2 mg/ml 20-25°C Protect from light
8 Hour
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml 2-8°C Protect from light
5 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml 20-25°C Protect from light
6 Hour
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,4 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,4 mg/ml 20-25°C Protect from light
6 Hour

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