Last update :
23/11/2022
References   References 4694  
Type : Journal
Web link : https://doi.org/10.1371/ journal.pone.0270206

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Coache D, Friciu M, Bernine Marcellin R, Bonnemain L, Viau A, Gaëlle Roullin V, Forest J.M, Leclair G.
Title : Stability evaluation of compounded hydroxyurea 100 mg/mL oral liquids using a novel analytical method involving chemical derivatization.
Reference : PlosOne 2022

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
Oral solutionHydroxyurea Anticancer drug
Stability in solutions Plastic bottle Tablets 5000 mg
® = Mylan
Orablend® >> 50 mL
23-27°C Protect from light
90 Day
Stability in solutions Plastic bottle Tablets 5000 mg
® = Bristol Myers Squibb
Orablend® >> 50 mL
23-27°C Protect from light
90 Day
Stability in solutions Plastic bottle Powder 5000 mg
® = ?
Orablend® >> 50 mL
23-27°C Protect from light
90 Day
Stability in solutions Syringe Tablets 300 mg
® = Mylan
Orablend® >> 3 mL
23-27°C Protect from light
14 Day
Stability in solutions Syringe Powder 300 mg
® = ?
Orablend® >> 3 mL
23-27°C Protect from light
14 Day
Stability in solutions Syringe Tablets 300 mg
® = Bristol Myers Squibb
Orablend® >> 3 mL
23-27°C Protect from light
14 Day

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