Last update :
28/04/2024
References   References 3928  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4276

Research teams : Waltham - TESARO Inc, Waltham
Authors : Wu G, Yeung S, Chen F.
Title : Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride.
Reference : Int J Pharm Compound ; 21, 1: 76-82. 2017

Level of Evidence : 
Level of evidence A+
Physical stability : 
Particle counting Turbidimetry Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionPalonosetron hydrochloride Antiemetic
Compatible 2.5 µg/ml + InjectionRolapitant 1.65 mg/ml + None
InjectionRolapitant Antiemetic
Compatible 1.65 mg/ml + InjectionPalonosetron hydrochloride 2.5 µg/ml + None
Stability of mixtures
Glass None 2-8°C Protect from light
Injection Rolapitant 1,65 mg/ml
Injection Palonosetron hydrochloride 2,28 µg/ml
7 Day
Glass None 20-25°C Protect from light
Injection Rolapitant 1,65 mg/ml
Injection Palonosetron hydrochloride 2,28 µg/ml
2 Day
Cristal Zenith® None 2-8°C Protect from light
Injection Rolapitant 1,65 mg/ml
Injection Palonosetron hydrochloride 2,28 µg/ml
7 Day
Cristal Zenith® None 20-25°C Protect from light
Injection Rolapitant 1,65 mg/ml
Injection Palonosetron hydrochloride 2,28 µg/ml
2 Day

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