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References   References 263  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/50/4/698
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Pearson SD, Trissel LA.
Title : Stability and compatibility of minocycline hydrochloride and rifampicin in intravenous solutions at various temperatures.
Reference : Am J Hosp Pharm ; 50: 698-702. 1993
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
List of drugs
InjectionMinocycline hydrochloride Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 24°C Not specified
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Not specified
7 Day
Compatible 0,1 mg/ml + InjectionRifampicin 0,1 mg/ml + Sodium chloride 0,9%
InjectionRifampicin Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 24°C Not specified
8 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Not specified
72 Hour
Compatible 0,1 mg/ml + InjectionMinocycline hydrochloride 0,1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 24°C Not specified
Injection Minocycline hydrochloride 0,1 mg/ml
Injection Rifampicin 0,1 mg/ml
8 Hour
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
Injection Minocycline hydrochloride 0,1 mg/ml
Injection Rifampicin 0,1 mg/ml
72 Hour
  Mentions Légales