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References   References 2196  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/64/11/1209
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Trusley C, Ben M, Kupiec TC.
Title : Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during Y-site administration.
Reference : Am J Health-Syst Pharm ; 64, 11: 1209-1213. 2007
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
List of drugs
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 15 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + InjectionFentanyl citrate 50 µg/ml + Glucose 5%
Compatible 50 µg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + Glucose 5%
Compatible 50 µg/ml + InjectionMorphine sulfate 15 mg/ml + Glucose 5%
Compatible 50 µg/ml + InjectionPethidine hydrochloride 10 mg/ml + Glucose 5%
Compatible 50 µg/ml + InjectionSufentanil citrate 0.0125 mg/ml + Glucose 5%
InjectionPethidine hydrochloride Analgesic
Compatible 10 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionSufentanil citrate Analgesic
Compatible 0.0125 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
Stability of mixtures
Glass None 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Fentanyl citrate 25 µg/ml
4 Hour
Glass None 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Hydromorphone hydrochloride 0,25 mg/ml
4 Hour
Glass None 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Morphine sulfate 7,7 mg/ml
4 Hour
Glass None 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Sufentanil citrate 7 mg/ml
4 Hour
Glass None 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Sufentanil citrate 0.0062 mg/ml
4 Hour
Glass None 25°C
Injection Palonosetron hydrochloride 25 µg/ml
Injection Pethidine hydrochloride 5,5 mg/ml
4 Hour
  Mentions Légales