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References   References 1931  
Type : Journal
Research teams : Ottawa - The Ottawa Hospital, department of Pharmacy
Authors : Donnely RF.
Title : Physical compatibility and chemical stability of bupivacaine and hydromorphone in polypropylene syringes.
Reference : Can J Hosp Pharm ; 4: 230-235. 2004
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionBupivacaine hydrochloride Local anesthetic
Compatible 2,5 mg/ml + InjectionHydromorphone hydrochloride 0,02 & 0,04 mg/ml + Sodium chloride 0,9%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0,02 & 0,04 mg/ml + InjectionBupivacaine hydrochloride 2,5 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 22°C Light
Injection Hydromorphone hydrochloride 0,02 & 0,04 mg/ml
Injection Bupivacaine hydrochloride 2,5 mg/ml
91 Day
Polypropylen Syringe Sodium chloride 0,9% 6°C Protect from light
Injection Hydromorphone hydrochloride 0,02 & 0,04 mg/ml
Injection Bupivacaine hydrochloride 2,5 mg/ml
91 Day
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