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References   References 1506  
Type : Journal
Web link : http://dx.doi.org/10.1136/ejhpharm-2014-000539
Research teams : Barcelona - Hopital Clinic of Barcelona
Authors : Lopez-Cabezas C, Guerrero L, Molas G, Anglada H, Soy D.
Title : Physicochemical compatibility of high concentration drugs usually Y-site administered in intensive care units.
Reference : EJHP ;22:107-112. 2015
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionClonidine hydrochloride Antihypertensive
Compatible 0.0075 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + Sodium chloride 0,9%
Compatible 0.0075 mg/ml + InjectionFurosemide 2 mg/ml + Sodium chloride 0,9%
Compatible 0.0075 mg/ml + InjectionHeparin sodium 50 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + InjectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + InjectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 8 mg/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 8 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Incompatible 8 mg/ml + InjectionFurosemide 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionFurosemide 2 mg/ml + Glucose 5%
Compatible 8 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionMidazolam hydrochloride 4 mg/ml + Glucose 5%
Incompatible 8 mg/ml + InjectionMidazolam hydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 8 mg/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 8 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionFurosemide 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + InjectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 40 µg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEsomeprazole sodium Proton pump inhibitor
Compatible 0.32 mg/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + Sodium chloride 0,9%
Incompatible 0.32 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.32 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionEpinephrine hydrochloride 40 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionFlumazenil 0.04 mg/ml + Sodium chloride 0,9%
Compatible 0.32 mg/ml + InjectionFurosemide 2 mg/ml + Sodium chloride 0,9%
Compatible 0.32 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.32 mg/ml + InjectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFentanyl citrate Analgesic
Compatible 30 µg/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + InjectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + InjectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFlumazenil Antidote
Compatible 0.04 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Compatible 2 mg/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + Sodium chloride 0,9%
Incompatible 2 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 50 UI/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 UI/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMethadone hydrochloride Analgesic
Compatible 0.2 mg/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionFurosemide 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionHeparin sodium 50 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + InjectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 4 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + Glucose 5%
Incompatible 4 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + Sodium chloride 0,9%
Compatible 4 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 4 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + InjectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + InjectionRemifentanil hydrochloride 20 µg/ml + NaCl 0,9% or Glucose 5%
InjectionMorphine hydrochloride Analgesic
Compatible 1 mg/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.32 mg/ml + InjectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPantoprazole sodium Proton pump inhibitor
Compatible 0.32 mg/ml + InjectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + InjectionRemifentanil hydrochloride 20 µg/ml + NaCl 0,9% or Glucose 5%
InjectionRemifentanil hydrochloride Analgesic
Compatible 20 µg/ml + InjectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 20 µg/ml + InjectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
Injection Dopamine hydrochloride 8 mg/ml
Injection Dobutamine hydrochloride 8 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
Injection Dopamine hydrochloride 8 mg/ml
Injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
Injection Dobutamine hydrochloride 8 mg/ml
Injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
Injection Pantoprazole sodium 0.32 mg/ml
Injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
Injection Midazolam hydrochloride 4 mg/ml
Injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene Sodium chloride 0,9% 22-25°C Protect from light
Injection Esomeprazole sodium 0.32 mg/ml
Injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene Glucose 5% 22-25°C Protect from light
Injection Dobutamine hydrochloride 8 mg/ml
Injection Midazolam hydrochloride 4 mg/ml
24 Hour
  Mentions Légales