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References   References 1420  
Type : Journal
Web link : https://doi.org/10.1046/j.1365-2710.1999.00208.x
Research teams : West Point - Merck and Co
Authors : Bergquist PA, Hunke WA, Reed RA, Manas D, Forsyth RJ, Kenney RR, Cook J, Holahan M.
Title : Compatibility of tirofiban HCl with dopamine HCl, famotidine, sodium heparin, lidocaine HCl and potassium chloride during simulated Y-site administration.
Reference : J Clin Pharm Ther ; 24: 125-132. 1999
Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
List of drugs
injectionDopamine hydrochloride Cardiotonic
Compatible 0.2 & 3.2 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionFamotidine Antihistamine (H2)
Compatible 0.2 & 4 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 40 & 100 UI/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 1 & 20 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 10 & 40 mEq/l + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionTirofiban Anticoagulant
Compatible 50 µg/ml + injectionDopamine hydrochloride 0.2 & 3.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionFamotidine 0.2 & 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionHeparin sodium 40 & 100 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionLidocaine hydrochloride 1 & 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionPotassium chloride 10 & 40 mEq/l + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Dopamine hydrochloride 0.1 & 1.6 mg/ml
injection Tirofiban 25 µg/ml
4 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Famotidine 0.1 & 2 mg/ml
injection Tirofiban 25 µg/ml
4 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Lidocaine hydrochloride 0.5 & 10 mg/ml
injection Tirofiban 25 µg/ml
4 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Heparin sodium 20 & 50 UI/ml
injection Tirofiban 25 µg/ml
4 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Potassium chloride 5 & 20 mEq/l
injection Tirofiban 25 µg/ml
4 Hour
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