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References   References 1067  
Type : Journal
Research teams : Kassel - Institut für Ökologische Chemie und Ökotoxikologie
Authors : Zeidler C, Dettmering D, Schrammel W, Spieteller M.
Title : Compatibility of various drugs used in intensive care medicine in polyethylene, PVC and glass infusion containers.
Reference : EJHP ; 5: 106-110. 1999
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Stability indicating capability inadequately assessed
List of drugs
InjectionAciclovir sodium Antiviral
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 5 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 5 mg/ml 4°C Protect from light
24 Hour
InjectionCeftazidime Antibiotic
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 10 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
24 Hour
InjectionClindamycin phosphate Antibiotic
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 3 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 3 mg/ml 4°C Protect from light
24 Hour
InjectionDiazepam Anxiolytic
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,04 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,04 mg/ml 4°C Protect from light
24 Hour
InjectionDiltiazem hydrochloride Anti-arrhythmic
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,05 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,05 mg/ml 4°C Protect from light
24 Hour
InjectionDobutamine hydrochloride Cardiotonic
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,5 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,5 mg/ml 4°C Protect from light
24 Hour
InjectionHeparin sodium Anticoagulant
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 7 UI/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 7 UI/ml 4°C Protect from light
24 Hour
InjectionImipenem - cilastatin sodium Antibiotic
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 2,5 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 2,5 mg/ml 4°C Protect from light
24 Hour
InjectionIsosorbide dinitrate Vasodilator
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
24 Hour
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,125 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,125 mg/ml 4°C Protect from light
24 Hour
InjectionMidazolam hydrochloride Anxiolytic
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,035 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,035 mg/ml 4°C Protect from light
24 Hour
InjectionNimodipine Antihypertensive
Factors which affect stability Container Polyvinyl chloride Induces Absorption
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,01 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,01 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,01 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,01 mg/ml 4°C Protect from light
24 Hour
InjectionNitroglycerin Vasodilator
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,01 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,01 mg/ml 4°C Protect from light
24 Hour
InjectionRanitidine hydrochloride Antihistamine (H2)
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,25 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,25 mg/ml 4°C Protect from light
24 Hour
InjectionTriflupromazine hydrochloride Neuroleptic
Factors which affect stability Container Polyvinyl chloride22°C Induces Adsorption
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,02 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.02 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.02 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 22°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
24 Hour
  Mentions Légales