Last update :
05/12/2025
References   References 4989  
Type : Manufacturer

Research teams :
Authors :
Title : Extended dilution stability study report of cyclophosphamide concentrate for solution for infusion at room temperature and refrigerated condition ( 2-8°C) - Personal communication - July 2025
Reference : Dr REDDY 2023

Level of Evidence : 
Manufacturer's stability data
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
injectionCyclophosphamide Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 2 mg/ml 2-8°C Protect from light
5 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 2 mg/ml 25°C Light
60 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
6 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 25°C Light
24 Hour
Stability in solutions Polyolefine Glucose 5% 2 mg/ml 2-8°C Protect from light
6 Day
Stability in solutions Polyolefine Glucose 5% 2 mg/ml 25°C Light
60 Hour
Stability in solutions Polyolefine Glucose 5% 20 mg/ml 2-8°C Protect from light
3 Day
Stability in solutions Polyolefine Glucose 5% 20 mg/ml 25°C Light
24 Hour
Compatible + Sodium chloride 0,9%
Compatible + Glucose 5%

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