Last update :
21/02/2024
References   References 4748  
Type : Journal
Web link : https://doi.org/10.3390/ pharmaceutics15020309

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Linxweiler H, Thiesen J, Krämer I.
Title : Physicochemical Stability of Generic Thiotepa Concentrate and Ready-to-Administer Infusion Solutions for Conditioning Treatment.
Reference : Pharmaceutics ,15, 309. 2023

Level of Evidence : 
Level of evidence A+
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionThiotepa Anticancer drug
Factors which affect stability Temperature 25°C Induces Reduced stability
Factors which affect stability Concentration Reduced concentration Induces Reduced stability
Stability in solutions Glass Water for Injection 10 mg/ml 2-8°C Not specified
14 Day
Stability in solutions Glass Water for Injection 10 mg/ml 25°C Light
1 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 1 & 2 & 3 mg/ml 2-8°C Not specified
14 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1 & 2 & 3 mg/ml 25°C Light
1 Day
Stability in solutions Polyolefine Glucose 5% 1 mg/ml 25°C Light
3 Day
Stability in solutions Polyolefine Glucose 5% 2 mg/ml 25°C Light
5 Day
Stability in solutions Polyolefine Glucose 5% 3 mg/ml 25°C Light
7 Day

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