Last update :
09/04/2024
References   References 4267  
Type : Journal
Icone.pdf
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Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : D'Huart E, Vigneron J, Clarot I, Demoré B.
Title : Physicochemical stability of nefopam and nefopam/droperidol solutions in polypropylene syringes for intensive care units.
Reference : EJHP 2019

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Measurement of osmolality 
Comments : 

List of drugs
InjectionDroperidol Neuroleptic
Compatible 0,052 mg/ml + InjectionNefopam 2,5 mg/ml + Sodium chloride 0,9%
InjectionNefopam Analgesic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 2,5 mg/ml 20-25°C Light
48 Hour
Compatible 2,5 mg/ml + InjectionDroperidol 0,052 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 20-25°C Light
Injection Nefopam 2,5 mg/ml
Injection Droperidol 0,052 mg/ml
48 Hour

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