Last update :
22/01/2021
References   References 4137  
Type : Journal

Research teams : Plymouth - Derriford Hospital,Department of Pharmacy
Authors : Patel T, Sewell G.
Title : Short Report : Extended Stability Studies on Bortezomib Injection and Infusions of Cisplatin and Pemetrexed (all Accord Healthcare).
Reference : Newsletter Stabilis 41;2-6 2018

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionBortezomib Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 25°C Protect from light
7 Day
Stability in solutions Glass Sodium chloride 0,9% 2,5 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,9% 2,5 mg/ml 25°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 25°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 2,5 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 2,5 mg/ml 25°C Protect from light
7 Day
InjectionCisplatin Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 0,006 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 0,06 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 0,12 mg/ml 25°C Protect from light
21 Day
InjectionPemetrexed disodium Anticancer drug
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 12,5 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 12,5 mg/ml 25°C Protect from light
2 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 2,5 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 2,5 mg/ml 25°C Protect from light
2 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 7,5 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 7,5 mg/ml 25°C Protect from light
2 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 12,5 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 12,5 mg/ml 25°C Protect from light
2 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 2,5 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 2,5 mg/ml 25°C Protect from light
2 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 7,5 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 7,5 mg/ml 25°C Protect from light
2 Day

  Mentions Légales