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References   References 4069  
Type : Journal
Web link : https://ejhp.bmj.com/content/25/e2/e109
Research teams : Lausanne - University Hospital, Department of Pharmacy
Authors : Palmero D, Chavan E, Berger-Gryllaki M, Tolsa J-F, Di Paolo E, Pannatier A, Henry H, Sadeghipour F.
Title : Stability of prostaglandin E1 solutions stored in polypropylene syringes for continuous intravenous administration to newborns.
Reference : EJHP ; 25, e2 2018
Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified
List of drugs
InjectionAlprostadil Vasodilator
Stability in solutions Polypropylene Glucose 10% 1.5 µg/ml 28-32°C Light
48 Hour
Stability in solutions Polypropylene Glucose 10% 15 µg/ml 28-32°C Light
48 Hour
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