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References   References 40  
Type : Journal
Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Dine T, Lebegue S, Benaji B, Gressier B, Segard V, Goudaliez F, Luyckx M, Brunet C, Mallevais ML, Kablan J, Cazin M, Cazin JC.
Title : Stability and compatibility studies of four cytostatic agents (fluorouracil, dacarbazine, cyclophosphamide and ifosfamide) with PVC infusion bags.
Reference : Pharm Sci Communications ; 4: 97-101. 1994
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Unencrypted results (eg graphic)
Degradation products not observed in real conditions
List of drugs
InjectionCyclophosphamide Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
30 Day
InjectionDacarbazine Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,6 mg/ml 4°C Protect from light
30 Day
InjectionFluorouracil Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
30 Day
InjectionIfosfamide Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 30 mg/ml 4°C Protect from light
30 Day
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