Last update :
03/05/2024
References   References 3448  
Type : Journal
Web link : http://www.em-consulte.com/article/840329/article/physicochemical-stability-study-of-a-new-trimix-fo

Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Vieillard V, Eychenne N, Astier A, Yiou R, Deffaux C, Paul M.
Title : Physicochemical stability study of a new Trimix formulation for treatment of erectile dysfunction.
Reference : Ann Pharm Fr ; 71, 5: 358-363. 2013

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Measurement of osmolality Water loss by evaporation 
Comments : 
Degradation products identified and quantified

List of drugs
InjectionAlprostadil Vasodilator
InjectionPapaverine hydrochloride Vasodilator
InjectionUrapidil Antihypertensive
Stability of mixtures
Polypropylene Sodium chloride 0,9% 2-8°C Protect from light
Injection Papaverine hydrochloride 15 mg/ml
Injection Alprostadil 15 µg/ml
Injection Urapidil 2 mg/ml
55 Day

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