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References   References 3296  
Type : Journal
Research teams : Grenade - Faculty of Science, Department of Analytical Chemistry
Authors : Salmeron-Garcia A, Navas N, Martin A, Roman E, Cabeza J, Capitan-Vallvey L.F
Title : Determination of Tramadol, Metamizole, Ropivacaine, and Bupivacaine in Analgesic Mixture Samples by HPLC with DAD Detection.
Reference : J Chromatographic Sci ; 47: 1-7. 2009
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
InjectionBupivacaine hydrochloride Local anesthetic
InjectionRopivacain hydrochloride Local anesthetic
InjectionTramadol hydrochloride Analgesic
Stability of mixtures
Polyolefine Sodium chloride 0,9% 25°C With or without light
Injection Tramadol hydrochloride 4 mg/ml
Injection Bupivacaine hydrochloride 1,2 mg/ml
15 Day
Polyolefine Sodium chloride 0,9% 25°C With or without light
Injection Tramadol hydrochloride 4 mg/ml
Injection Ropivacain hydrochloride 2 mg/ml
15 Day
Polyolefine Sodium chloride 0,9% 4°C Protect from light
Injection Tramadol hydrochloride 4 mg/ml
Injection Bupivacaine hydrochloride 1,2 mg/ml
15 Day
Polyolefine Sodium chloride 0,9% 4°C Protect from light
Injection Tramadol hydrochloride 4 mg/ml
Injection Ropivacain hydrochloride 2 mg/ml
15 Day
  Mentions Légales