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References   References 32  
Type : Journal
Research teams : Lund - University Hospital of Lund, Hospital Pharmacy
Authors : Nyhammar EK, Johansson SG, Seiving BE.
Title : Stability of doxorubicin and vincristine sulfate in two portable infusion-pump reservoirs.
Reference : Am J Health-Syst Pharm ; 53: 1171-1173. 1996
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products quantified but not identified
List of drugs
InjectionDoxorubicin hydrochloride Anticancer drug
Compatible 1,67 mg/ml + InjectionVincristine sulfate 0,036 mg/ml + Sodium chloride 0,9%
InjectionVincristine sulfate Anticancer drug
Compatible 0,036 mg/ml + InjectionDoxorubicin hydrochloride 1,67 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 35°C Protect from light
Injection Doxorubicin hydrochloride 1,67 mg/ml
Injection Vincristine sulfate 0,036 mg/ml
4 Day
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
Injection Doxorubicin hydrochloride 1,67 mg/ml
Injection Vincristine sulfate 0,036 mg/ml
7 Day
  Mentions Légales