Last update :
18/04/2024
References   References 302  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/22/2588

Research teams : Seattle - Immunex Corporation
Authors : Murray KM, Erkkila D, Gombotz WR, Pankey S.
Title : Stability of thiotepa (lyophilized) in 0.9% sodium chloride injection.
Reference : Am J Health-Syst Pharm ; 54: 2588-2591. 1997

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Degradation products identified and quantified

List of drugs
InjectionThiotepa Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 3 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 3 mg/ml 8°C Light
48 Hour

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