| Type : |
Journal |
|
| Research teams : |
Toledo - College of Pharmacy and Pharmaceutical Sciences, The University of Toledo |
| Authors : |
Alexander KS, Sundar S, White DB, Dollimore D. |
| Title : |
The Formulation Development and Stability of Spironolactone Suspension |
| Reference : |
Int J Pharm Compound ; 1, 3: 195-199. 1997 |
|
| Level of Evidence : |
|
| Physical stability : |
|
| Chemical stability : |
|
| Other methods : |
|
| Comments : |
|
List of drugs
 Spironolactone
|
 |
 |
PH |
PH 4.5 |
 |
 |
 |
 |
 |
600 mg
®= ? |
| Carboxymethylcellulose |
900 mg |
| Veegum® |
900 mg |
| Methylparaben |
120 mg |
| Propylparaben |
24 mg |
| Propylene glycol |
1.2 ml |
| Sorbitol |
70% 48 ml |
| Sodium acetate |
350 mg |
| Acetic acid |
36% 0.67 ml |
| Sodium bisulfite |
120 mg |
| Sodium edetate |
120 mg |
| Sodium saccharin |
24 mg |
| Pineapple aroma |
|
| Distilled water |
>> 120 ml |
|
30°C |
 |
| 90 |
 |
|
|
|
|
|
600 mg
®= ? |
| Carboxymethylcellulose |
900 mg |
| Veegum® |
900 mg |
| Methylparaben |
120 mg |
| Propylparaben |
24 mg |
| Propylene glycol |
1.2 ml |
| Sorbitol |
70% 48 ml |
| Sodium acetate |
350 mg |
| Acetic acid |
36% 0.67 ml |
| Sodium bisulfite |
120 mg |
| Sodium edetate |
120 mg |
| Sodium saccharin |
24 mg |
| Pineapple aroma |
|
| Distilled water |
>> 120 ml |
|
5°C |
|
| 90 |
|
|
|
|
|
