Last update :
21/02/2024
References   References 279  
Type : Journal

Research teams : Piscataway - State University of New Jersey, College of Pharmacy
Authors : Bailey LC, Cappel KM, Orosz ST.
Title : Stability of ceftriaxone sodium in injectable solutions stored frozen in syringes.
Reference : Am J Hosp Pharm ; 51: 2159-2161. 1994

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Method not shown but the article refers to a validated method

List of drugs
InjectionCeftriaxone disodium Antibiotic
Stability in solutions Polypropylen Syringe Glucose 5% 250 & 450 mg/ml -15°C Protect from light
56 Day
Stability in solutions Polypropylen Syringe Glucose 5% 250 & 450 mg/ml 20°C Protect from light
24 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 250 & 450 mg/ml 4°C Protect from light
10 Day
Stability in solutions Polypropylen Syringe Water for injection + antibacterial 250 mg/ml -15°C Protect from light
56 Day
Stability in solutions Polypropylen Syringe Water for injection + antibacterial 250 & 450 mg/ml 20°C Protect from light
24 Hour
Stability in solutions Polypropylen Syringe Water for injection + antibacterial 250 & 450 mg/ml 4°C Protect from light
10 Day
InjectionLidocaine hydrochloride Local anesthetic
Stability of mixtures
Polypropylene Water for Injection -15°C Protect from light
Injection Ceftriaxone disodium 450 mg/ml
Injection Lidocaine hydrochloride 10 mg/ml
56 Day
Polypropylene Water for Injection 20°C Protect from light
Injection Ceftriaxone disodium 450 mg/ml
Injection Lidocaine hydrochloride 10 mg/ml
24 Hour
Polypropylene Water for Injection 4°C Protect from light
Injection Ceftriaxone disodium 450 mg/ml
Injection Lidocaine hydrochloride 10 mg/ml
10 Day

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