Last update :
28/04/2024
References   References 2281  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2827

Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Ben M, Kupiec T, Trusley C, Trisel LA.
Title : Compatibility and stability of palonosetron hydrochloride with lactated Ringer's, Hetastarch in lactated electrolyte, an mannitol injections during simulated Y-site administration.
Reference : Int J Pharm Compound ; 12, 5: 460-462. 2008

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionHetastarch Various
Compatible 60 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Ringer’s lactate solution
InjectionMannitol Various
Compatible 150 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + None
InjectionPalonosetron hydrochloride Antiemetic
Stability in solutions Glass Ringer’s lactate solution 25 µg/ml 25°C Not specified
4 Hour
Compatible 50 µg/ml + InjectionHetastarch 60 mg/ml + Ringer’s lactate solution
Compatible 50 µg/ml + InjectionMannitol 150 mg/ml + None

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