Last update :
28/04/2024
References   References 2279  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Kupiec T, Trusley C, Ben M, Trissel LA.
Title : Physical and chemical stability of palonosetron hydrochloride with five common parenteral drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 65, 18: 1735-1759. 2008

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionAtropine sulfate Antimuscarinic
Compatible 0.4 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + InjectionAtropine sulfate 0.4 mg/ml + Glucose 5%
Compatible 50 µg/ml + InjectionFamotidine 2 mg/ml + Glucose 5%
Compatible 50 µg/ml + InjectionHeparin sodium 100 UI/ml + Glucose 5%
Compatible 50 µg/ml + InjectionLidocaine hydrochloride 10 mg/ml + Glucose 5%
Compatible 50 µg/ml + InjectionPotassium chloride 100 mEq/l + Glucose 5%
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Light
Injection Atropine sulfate 0,19 mg/ml
Injection Palonosetron hydrochloride 25 µg/ml
4 Hour
Glass Glucose 5% 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Heparin sodium 50 UI/ml
4 Hour
Glass Glucose 5% 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Lidocaine hydrochloride 5,3 mg/ml
4 Hour
Glass Glucose 5% 25°C Light
Injection Potassium chloride 50 mEq/l
Injection Palonosetron hydrochloride 25 µg/ml
4 Hour
Glass Glucose 5% 25°C Light
Injection Palonosetron hydrochloride 25 µg/ml
Injection Famotidine 1 mg/ml
4 Hour

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