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References   References 2055  
Type : Journal
Web link : https://doi.org/10.1016/j.ijpharm.2005.10.017
Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Negro S, Reyes R, Azuara ML, Sanchez Y, Barcia E.
Title : Morphine, haloperidol and hyoscine N-butyl bromide combined in sc infusion solutions : compatibility and stability evaluation in terminal oncology patients.
Reference : Int J Pharm ; 307: 278-284. 2006
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
Water loss by evaporation PH measurement 
Comments : 
List of drugs
InjectionHaloperidol lactate Neuroleptic
InjectionMorphine hydrochloride Analgesic
InjectionScopolamine N-butyl bromide Antimuscarinic
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Protect from light
Injection Scopolamine N-butyl bromide 5 & 6,67 mg/ml
Injection Haloperidol lactate 0,42 & 0,62 mg/ml
Injection Morphine hydrochloride 1,67>> 10 mg/ml
15 Day
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