Last update :
28/04/2024
References   References 2046  
Type : Journal
Web link : http://aac.asm.org/cgi/content/abstract/47/6/1991

Research teams : Los Angeles - University of Southern california, School of Pharmacy
Authors : Sprauten PF, Beringer PM, Louie ST, Synold TW, Gill MA.
Title : Stability and antibacterial activity of cefepime during continuous infusion.
Reference : Antimicrob Agents Chemother ; 47: 1991-1994. 2003

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Water loss by evaporation 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionCefepime dihydrochloride Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Ethylene vinyl acetate Glucose 5% 2,9 mg/ml -20°C Protect from light
14 Day
Stability in solutions Ethylene vinyl acetate Glucose 5% 2,9 mg/ml 25°C Protect from light
24 Hour
Stability in solutions Ethylene vinyl acetate Glucose 5% 2,9 mg/ml 4°C Protect from light
7 Day

  Mentions Légales