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References   References 199  
Type : Journal
Research teams : Baltimore - University of Maryland, School of Pharmacy
Authors : Hassan E, Leslie J, Martir-Herrero ML.
Title : Stability of labetalol hydrochloride with selected critical care drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 51: 2143-2145. 1994
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionDobutamine hydrochloride Cardiotonic
Compatible 2.5 mg/ml + InjectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + InjectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
InjectionLabetalol hydrochloride Beta-blocker
Compatible 1 mg/ml + InjectionDobutamine hydrochloride 2.5 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionDopamine hydrochloride 1.6 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionMorphine sulfate 0.5 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionNitroglycerin 0.2 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionRanitidine hydrochloride 0.6 mg/ml + Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 0.5 mg/ml + InjectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
InjectionNitroglycerin Vasodilator
Compatible 0.2 mg/ml + InjectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0.6 mg/ml + InjectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 20°C-25°C Light
Injection Labetalol hydrochloride 1 mg/ml
Injection Dobutamine hydrochloride 2,5 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
Injection Labetalol hydrochloride 1 mg/ml
Injection Dopamine hydrochloride 1,6 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
Injection Labetalol hydrochloride 1 mg/ml
Injection Morphine sulfate 0,5 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
Injection Labetalol hydrochloride 1 mg/ml
Injection Nitroglycerin 0,2 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
Injection Labetalol hydrochloride 1 mg/ml
Injection Ranitidine hydrochloride 0,6 mg/ml
4 Hour
  Mentions Légales