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References   References 1845  
Type : Journal
Research teams : Friedberg - Fresenius Kabi, Innovation Centre i.v. Therapies
Authors : Müller HJ, Haker I.
Title : The stability of amoxicillin, ampicillin, benzylpenicillin, flucloxacillin, mezlocillin and piperacillin in isotonic saline solutions when stored in an innovative infusion container (Freeflex container).
Reference : EJHP ; 6: 106-111. 2003
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionAmoxicillin sodium Antibiotic
Stability in solutions Polypropylene Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 5 mg/ml 25°C Protect from light
24 Hour
InjectionAmpicillin sodium Antibiotic
Stability in solutions Polypropylene Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
4 Day
InjectionFlucloxacillin sodium Antibiotic
Stability in solutions Polypropylene Sodium chloride 0,9% 10 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 10 mg/ml 25°C Protect from light
4 Day
InjectionPiperacillin sodium Antibiotic
Stability in solutions Polypropylene Sodium chloride 0,9% 20 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 20 mg/ml 25°C Protect from light
7 Day
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