Last update :
10/07/2024
References   References 1491  
Type : Journal

Research teams : Groningen - University of Groningen, Department of Pharmacy
Authors : Brouwers JRBJ, van Doorne H, Meevis RF, Boersma FP.
Title : Stability of sufentanil citrate and sufentanil citrate/bupivacaine mixture in portable infusion pump reservoirs.
Reference : Eur Hosp Pharm ; 1: 12-14. 1995

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionBupivacaine hydrochloride Local anesthetic
injectionSufentanil citrate Analgesic
Factors which affect stability Container Polyvinyl chloride[ 20 µg / ml ] Induces Adsorption
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,02 mg/ml 4°C Protect from light
10 Day
Stability of mixtures
Polyvinyl chloride Not specified 26°C Not specified
injection Sufentanil citrate 0,02 mg/ml
injection Bupivacaine hydrochloride 3 mg/ml
10 Day
Polyvinyl chloride Not specified 37°C Not specified
injection Sufentanil citrate 0,02 mg/ml
injection Bupivacaine hydrochloride 3 mg/ml
10 Day
Polyvinyl chloride Not specified 4°C Protect from light
injection Sufentanil citrate 0,02 mg/ml
injection Bupivacaine hydrochloride 3 mg/ml
10 Day

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