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References   References 142  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/49/3/619
Research teams : Poitiers - Université de Poitiers, Faculté de Médecine et Pharmacie
Authors : Rochard EB, Barthes DMC, Courtois PY.
Title : Stability of fluorouracil, cytarabine, or doxorubicin hydrochloride in ethylene vinylacetate portable infusion-pump reservoirs.
Reference : Am J Hosp Pharm ; 49: 619-623. 1992
Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence A Fluorouracil
Level of evidence B Doxorubicin hydrochloride
Level of evidence B Cytarabine
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Fluorouracil
Stability defined as 95% of the initial concentrationFluorouracil
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Doxorubicin hydrochloride
Stability defined as 90% of the initial concentrationDoxorubicin hydrochloride
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Cytarabine
Stability defined as 90% of the initial concentrationCytarabine
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionCytarabine Anticancer drug
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 & 25 mg/ml 22°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 & 25 mg/ml 35°C Protect from light
7 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 & 25 mg/ml 4°C Protect from light
28 Day
InjectionDoxorubicin hydrochloride Anticancer drug
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 0,5 mg/ml 22°C Protect from light
14 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 0,5 mg/ml 35°C Protect from light
14 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 mg/ml 22°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 mg/ml 35°C Protect from light
7 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 mg/ml 4°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 0,5 mg/ml 4°C Protect from light
14 Day
Stability in solutions Ethylene vinyl acetate Glucose 5% 0,5 mg/ml 4°C Protect from light
28 Day
InjectionFluorouracil Anticancer drug
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 22°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 35°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate None 50 mg/ml 22°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate None 50 mg/ml 35°C Protect from light
28 Day
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