| Type : |
Journal |
| Web link : |
http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=174 |
|
| Research teams : |
Toledo - College of Pharmacy and Pharmaceutical Sciences, The University of Toledo |
| Authors : |
Alexander KS, Kothapalli MR, Dollimor D. |
| Title : |
Stability of an extemporaneously formulated levothyroxine sodium syrup compounded from commercial tablets. |
| Reference : |
Int J Pharm Compound : 60-63. 1997 |
|
| Level of Evidence : |
|
| Physical stability : |
|
| Chemical stability : |
|
| Other methods : |
|
| Comments : |
|
List of drugs
 Levothyroxine
|
 |
 |
 |
 |
40 mg
Synthroid® |
| Sorbitol |
70% 500 ml |
| Ethanol |
50 ml |
| Glycerin |
250 ml |
| methylparaben |
1 g |
| Propylparaben |
200 mg |
| propylene glycol |
>> 10 ml |
| sodium bisulfite |
1g |
| Sodium edetate |
1 g |
| NaH2PO4 |
4.768 g |
| Sodium phosphate |
17.719 g |
| Banana flavor |
10 ml |
| Purified water |
>> 1000 ml |
|
25°C |
 |
| 15 |
 |
|
|
|
|
|
40 mg
Synthroid® |
| Sorbitol |
70% 500 ml |
| Ethanol |
50 ml |
| Glycerin |
250 ml |
| methylparaben |
1 g |
| Propylparaben |
200 mg |
| propylene glycol |
>> 10 ml |
| sodium bisulfite |
1g |
| Sodium edetate |
1 g |
| NaH2PO4 |
4.768 g |
| Sodium phosphate |
17.719 g |
| Banana flavor |
10 ml |
| Purified water |
>> 1000 ml |
|
5°C |
|
| 47 |
|
|
|
|
|
