Last update :
05/12/2025
InfoStab
Infostab
List of drugs
List of drugs
Summary lists
Summary lists
Search for compatibilities
Search for compatibilities
Y-site compatibility table
Y-site compatibility table
References
References
Research teams
Research teams
valistab
valistab
Poster
Poster
Links
Links
Sponsors
Sponsors
Authors
Authors
User’s guide
User’s guide
Newsletter
Newsletter
References   References 2009  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2232
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Zhang Y.
Title : Physical and chemical stability of palonosetron hydrochloride with fluorouracil and with gemcitabine hydrochloride during simulated Y-site administration.
Reference : Int J Pharm Compound ; 2005, 9, 4: 320-322. 2005
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
No comments for the degradation products
List of drugs
injectionFluorouracil Anticancer drug
Compatible 16 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionGemcitabine hydrochloride Anticancer drug
Compatible 10 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionFluorouracil 16 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionGemcitabine hydrochloride 10 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Light
injection Fluorouracil 0,08 mg/ml
injection Palonosetron hydrochloride 26 µg/ml
4 Hour
Glass Glucose 5% 25°C Light
injection Gemcitabine hydrochloride 0.105 mg/ml
injection Palonosetron hydrochloride 26 µg/ml
4 Hour
  Mentions Légales