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References   References 3420  
Type : Journal
Web link : 10.1177/1078155214526267
Icone.pdf
693Ko
Research teams : Paris - University Hospital Saint Louis, Department of Pharmacy
Authors : El Kateb N, Chaussard M, Bellenger P, Petit A, Faure P.
Title : Stability of an extemporaneously prepared bleomycin-lidocaine-epinephrine intradermal admixture used in dermatology
Reference : J Oncol Pharm Practice ; 21, 3: 178-187. 2014
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Degradation products quantified but not identified
List of drugs
InjectionBleomycin sulfate Anticancer drug
Stability in solutions Polypropylene Sodium chloride 0,9% 0,75 mg/ml 22°C Protect from light
7 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 0,75 mg/ml 4°C Protect from light
7 Day
InjectionEpinephrine hydrochloride Sympathomimetic
InjectionLidocaine hydrochloride Local anesthetic
Stability of mixtures
Polypropylene Sodium chloride 0,9% 22°C Not specified
Injection Epinephrine hydrochloride 3,5 µg/ml
Injection Lidocaine hydrochloride 3,5 mg/ml
Injection Bleomycin sulfate 0,75 mg/ml
1 Day
Polypropylene Sodium chloride 0,9% 4°C Not specified
Injection Epinephrine hydrochloride 3,5 µg/ml
Injection Lidocaine hydrochloride 3,5 mg/ml
Injection Bleomycin sulfate 0,75 mg/ml
3 Day
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