Last update :
16/07/2021
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This page permits the cross-consultation of the stability information.

Stability of pharmaceutical preparations
Factors which affect stability
Compatibility
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Compound Solvent References
Precipitation after 1 hourIncompatible
Injection Allopurinol sodium 3 mg/ml
NaHCO3 307
Immediate precipitationIncompatible
Injection Amiodarone hydrochloride 3 mg/ml
NaHCO3 200
Turbidity in one hourIncompatible
Injection Amiodarone hydrochloride 15 mg/ml
NaHCO3 3823
Immediate precipitationIncompatible
Injection Amiodarone hydrochloride 3 mg/ml
NaHCO3 205
Unspecified incompatibilityIncompatible
Injection Amiodarone hydrochloride
NaHCO3 3464
Turbidity in one hourIncompatible
Injection Amiodarone hydrochloride 6 mg/ml
NaHCO3 1611
Unspecified incompatibilityIncompatible
Injection Amoxicillin sodium
NaHCO3 3527
Unspecified incompatibilityIncompatible
Injection Amoxicillin sodium / clavulanic acid
NaHCO3 3545
Immediate precipitationIncompatible
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
NaHCO3 921
Immediate turbidityIncompatible
Injection Anidulafungin 0.5 mg/ml
NaHCO3 1982
Compatible
Injection Asparaginase 120 UI/ml
NaHCO3 150
Unspecified incompatibilityIncompatible
Injection Atracurium besylate
NaHCO3 3676
Unspecified incompatibilityIncompatible
Injection Atracurium besylate
NaHCO3 3629
Unspecified incompatibilityIncompatible
Injection Calcium gluconate
NaHCO3 3644
Chemical instabilityIncompatible
Injection Carmustine
NaHCO3 715
Compatible
Injection Cefoxitin sodium 1 mg/ml
NaHCO3 588
Unspecified incompatibilityIncompatible
Injection Cefpirome sulfate
NaHCO3 3677
Unspecified incompatibilityIncompatible
Injection Ceftazidime
NaHCO3 3543
Chemical instabilityIncompatible
Injection Ceftazidime
NaHCO3 3883
Compatible
Injection Ceftriaxone disodium 100 mg/ml
NaHCO3 150
Immediate precipitationIncompatible
Injection Ciprofloxacin lactate
NaHCO3 285
Precipitation after 15 minutesIncompatible
Injection Ciprofloxacin lactate 2 mg/ml
NaHCO3 288
Unspecified incompatibilityIncompatible
Injection Cisatracurium besylate
NaHCO3 3466
Immediate turbidityIncompatible
Injection Cisatracurium besylate 2 & 5 mg/ml
NaHCO3 299
Unspecified incompatibilityIncompatible
Injection Cisatracurium besylate
NaHCO3 3601
Immediate turbidityIncompatible
Injection Cisatracurium besylate 5 mg/ml
NaHCO3 3823
Chemical instabilityIncompatible
Injection Cisplatin
NaHCO3 3578
Unspecified incompatibilityIncompatible
Injection Clindamycin phosphate
NaHCO3 3526
Unspecified incompatibilityIncompatible
Injection Co-trimoxazole
NaHCO3 3583
Compatible
Injection Cyclophosphamide 20 mg/ml
NaHCO3 150
Compatible
Injection Cytarabine 0.6 mg/ml
NaHCO3 150
Unspecified incompatibilityIncompatible
Injection Dacarbazine
NaHCO3 3605
Compatible
Injection Daunorubicin hydrochloride 0.52 mg/ml
NaHCO3 150
Immediate precipitationIncompatible
Injection Dimenhydrinate
NaHCO3 2087
Precipitation after 15 minutesIncompatible
Injection Dobutamine hydrochloride 1 mg/ml
NaHCO3 1058
Precipitation after 6 hoursIncompatible
Injection Dobutamine hydrochloride 2 mg/ml
NaHCO3 1041
Unspecified incompatibilityIncompatible
Injection Dobutamine hydrochloride
NaHCO3 3606
Color changeIncompatible
Injection Dopamine hydrochloride
NaHCO3 732
Unspecified incompatibilityIncompatible
Injection Dopamine hydrochloride
NaHCO3 3638
Loss of turbidityIncompatible
Injection Doxorubicin hydrochloride liposome peg
NaHCO3 251
Chemical instabilityIncompatible
Injection Epinephrine hydrochloride 1 & 10 µg/ml
NaHCO3 2077
Unspecified incompatibilityIncompatible
Injection Epinephrine hydrochloride
NaHCO3 3642
Unspecified incompatibilityIncompatible
Injection Epirubicin hydrochloride
NaHCO3 3632
Unspecified incompatibilityIncompatible
Injection Esmolol hydrochloride
NaHCO3 3607
Compatible
Injection Etoposide 0.6 mg/ml
NaHCO3 150
Immediate precipitationIncompatible
Injection Fenoldopam mesylate 80 µg/ml
NaHCO3 1803
Precipitation after 30 minutesIncompatible
Injection Folinate calcium 10 mg/ml
NaHCO3 150
Compatible
Injection Furosemide 10 mg/ml
NaHCO3 3134
Precipitation after 1 hourIncompatible
Injection Gemcitabine hydrochloride 16 >> 20 mg/ml
NaHCO3 3262
Unspecified incompatibilityIncompatible
Injection Gentamicin sulfate
NaHCO3 3520
Production of gas bubblesIncompatible
Injection Gentamicin sulfate
NaHCO3 3643
Compatible
Injection Granisetron hydrochloride 1 mg/ml
NaHCO3 57
Unspecified incompatibilityIncompatible
Injection Haloperidol lactate
NaHCO3 3466
Unspecified incompatibilityIncompatible
Injection Haloperidol lactate 0,5 mg/ml
NaHCO3 3823
Compatible
Injection Heparin sodium 500 UI/ml
NaHCO3 150
Chemical instabilityIncompatible
Injection Hydroxocobalamin
NaHCO3 3932
Unspecified incompatibilityIncompatible
Injection Hydroxyzine dihydrochloride
NaHCO3 3600
Immediate turbidityIncompatible
Injection Idarubicin hydrochloride
NaHCO3 491
Chemical instabilityIncompatible
Injection Imipenem - cilastatin sodium
NaHCO3 21
Turbidity in 15 minutesIncompatible
Injection Isavuconazonium sulfate 1.5 mg/ml
NaHCO3 3829
Immediate precipitationIncompatible
Injection Ketamine hydrochloride 50 mg/ml
NaHCO3 2109
Unspecified incompatibilityIncompatible
Injection Labetalol hydrochloride
NaHCO3 1380
Precipitation after 6 hoursIncompatible
Injection Labetalol hydrochloride 1,25 >> 3,75 mg/ml
NaHCO3 1194
Unspecified incompatibilityIncompatible
Injection Labetalol hydrochloride
NaHCO3 3609
Immediate precipitationIncompatible
Injection Lansoprazole 0.55 mg/ml
NaHCO3 1625
Immediate precipitationIncompatible
Injection Levobupivacaine hydrochloride
NaHCO3 3507
Unspecified incompatibilityIncompatible
Injection Levofloxacine
NaHCO3 3920
Unspecified incompatibilityIncompatible
Injection Magnesium sulfate
NaHCO3 3838
Compatible
Injection Mesna 1.8 mg/ml
NaHCO3 150
Immediate turbidityIncompatible
Injection Midazolam hydrochloride 1 mg/ml
NaHCO3 176
Unspecified incompatibilityIncompatible
Injection Midazolam hydrochloride
NaHCO3 3466
Unspecified incompatibilityIncompatible
Injection Midazolam hydrochloride 2,1 mg/ml
NaHCO3 3823
Immediate precipitationIncompatible
Injection Midazolam hydrochloride 5 mg/ml
NaHCO3 150
Unspecified incompatibilityIncompatible
Injection Moxifloxacin
NaHCO3 3109
Production of gas bubblesIncompatible
Injection Nalbuphine hydrochloride 10 mg/ml
NaHCO3 150
Compatible
Injection Netilmicin sulfate 3 mg/ml
NaHCO3 1200
Immediate precipitationIncompatible
Injection Nicardipine hydrochloride
NaHCO3 3941
Immediate precipitationIncompatible
Injection Nicardipine hydrochloride
NaHCO3 3614
Immediate precipitationIncompatible
Injection Nicardipine hydrochloride 0.05 & 0.5 mg/ml
NaHCO3 44
Unspecified incompatibilityIncompatible
Injection Norepinephrine bitartrate
NaHCO3 642
Immediate precipitationIncompatible
Injection Ondansetron hydrochloride 2 mg/ml
NaHCO3 150
Precipitation after 1 hourIncompatible
Injection Ondansetron hydrochloride 0.1 mg/ml
NaHCO3 1396
Unspecified incompatibilityIncompatible
Injection Ondansetron hydrochloride
NaHCO3 3574
Production of gas bubblesIncompatible
Injection Oxacillin sodium 250 mg/ml
NaHCO3 150
Compatible
Injection Oxacillin sodium 250 mg/ml
NaHCO3 150
Unspecified incompatibilityIncompatible
Injection Oxaliplatin
NaHCO3 3634
Precipitation after 1 hourIncompatible
Injection Pantoprazole sodium
NaHCO3 2090
Production of gas bubblesIncompatible
Injection Paracetamol 200 mg/ml
NaHCO3 150
Unspecified incompatibilityIncompatible
Injection Phenylephrine hydrochloride
NaHCO3 3620
Unspecified incompatibilityIncompatible
Injection Piperacillin sodium
NaHCO3 3590
Unspecified incompatibilityIncompatible
Injection Piperacillin sodium / tazobactam
NaHCO3 3586
Unspecified incompatibilityIncompatible
Injection Posaconazole
NaHCO3 4380
Instability of the emulsion after 6 hoursIncompatible
Injection Propofol
NaHCO3 660
Unspecified incompatibilityIncompatible
Injection Remifentanil hydrochloride
NaHCO3 4501
Unspecified incompatibilityIncompatible
Injection Rifampicin
NaHCO3 3541
Precipitation after 4 hoursIncompatible
Injection Sargramostim 10 µg/ml
NaHCO3 335
Unspecified incompatibilityIncompatible
Injection Suxamethonium chloride
NaHCO3 3631
Unspecified incompatibilityIncompatible
Injection Tacrolimus
NaHCO3 3626
Unspecified incompatibilityIncompatible
Injection Temocilline
NaHCO3 2296
Unspecified incompatibilityIncompatible
Injection Thiopental sodium
NaHCO3 3466
Immediate precipitationIncompatible
Injection Thiopental sodium 60 mg/ml
NaHCO3 3823
Unspecified incompatibilityIncompatible
Injection Ticarcillin / clavulanic acid
NaHCO3 3587
Immediate precipitationIncompatible
Injection Verapamil hydrochloride
NaHCO3 1100
Compatible
Injection Verapamil hydrochloride 0.08 mg/ml
NaHCO3 1057
Precipitation after 30 minutesIncompatible
Injection Vincristine sulfate 0.1 mg/ml
NaHCO3 150
Precipitation after 30 minutesIncompatible
Injection Vindesine sulfate 0.1 mg/ml
NaHCO3 150
Immediate precipitationIncompatible
Injection Vinorelbine tartrate 1 mg/ml
NaHCO3 84
Unspecified incompatibilityIncompatible
Injection Voriconazole
NaHCO3 3566

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